Madeleine McCann's face made international news after she was reported missing from her family's vacation home in Praia da Luz, Portugal on May 3, 2007. According to The Telegraph, McCann was last seen tucked safely into bed when checked on by her parents and their friends that evening. 

However, Madeleine was reported missing shortly after 10pm, when her mother went to check her room and discovered the child was not there.

The ensuing investigation, which has lasted for years, targeted Madeleine's parents, Kate and Gerry McCann, as suspects, as well as a series of "mystery men" who eye witnesses claim to have seen carrying a child matching Madeleine's description.

One theory purported by Portuguese police suggested that "Madeleine had been killed by her parents by accident, possibly by being given an overdose of a sedative to make her sleep, that they had hidden the body, faked her abduction and then used the hire car weeks later to move her body to a burial location," reports The Telegraph.

However, in 2008, the McCanns were cleared as suspects.

Age progression pictures from National Center for Missing and Exploited Children

Posted by Official Find Madeleine Campaign on Wednesday, November 4, 2009

According to The Daily Mail, investigator Sir Bernard Hogan-Howe states that nine years after Madeleine's disappearance, the case may be reaching its end. However, Hogan-Howe indicates that, "There is a line of inquiry that remains to be concluded and it's expected that in the coming months that will happen."

In March 2016, Madeleine's case took a strange turn when an ad taken out in a Paraguayan newspaper claimed that Madeleine had been seen in Paraguay, reigniting rumors that the child was still alive.  However, Mirror reports that this theory has since been debunked.

Meanwhile, the McCanns continue their relentless search for Madeleine. Their official Facebook page, devoted to finding "Maddie," begs users not to give up on the hope that the child is still alive. 

May 12, 2016 marked what would have been Madeleine's 13th birthday.

If you have additional info on the Madeleine McCann case, please call +44 845 838 4699. And make sure to share this story to continue spreading the word about Madeleine.